[The effect of neoadjuvant chemotherapy on estrogen and progesterone receptor expression in breast carcinoma].

نویسندگان

  • Shu Wang
  • Jia-qing Zhang
  • Xin-min Qiao
  • De-qi Yang
  • Fu-zhong Tong
  • Hong-jun Liu
چکیده

OBJECTIVE To investigate the effect of neoadjuvant chemotherapy on estrogen receptor (ER) and progesterone receptor (PR) expression in breast carcinoma. METHODS Samples were obtained from 31 patients with breast carcinoma who received neo-adjuvant chemotherapy, ER or PR expressions were analyzed in preoperative core biopsies and final surgical specimens. RESULTS ER level was up-regulated in 13 (41.9%) out of 31 cases, PR level was up-regulated in 10 (32.3%). Both ER level and PR level were up-regulated in 8 (25.8%) out of 31 cases. CONCLUSIONS Neoadjuvant chemotherapy may impact the hormone receptor status, ER and PR expression re-analysis in final surgical specimens is recommended.

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عنوان ژورنال:
  • Zhonghua wai ke za zhi [Chinese journal of surgery]

دوره 43 15  شماره 

صفحات  -

تاریخ انتشار 2005